Brown University — Research Assistant

Job Description:

The Research Assistant is responsible for conducting DNA repair and DNA damage analysis studies on human normal and cancer cell models. Additional responsibilities will be to conduct immunohistochemistry analysis of tumor tissues. Under the supervision of the Principal Investigator, the Research Assistant will assist with maintaining human cancer cell cultures, evaluating DNA damage in response to chemotherapy and environmental genotoxins as well as staining tissue slides for expression of key DNA repair proteins. The Research Assistant will also be responsible for keeping supplies in stock and will provide technical support for research projects in general.

Research in Dr. Sobol’s lab focuses on mechanisms of DNA repair, PARP and NAD+ metabolism in human cells and the convergent role of these pathways in response to environmental genotoxins and chemotherapy. A major goal in the lab is to use biochemical, genetic, and imaging modalities to study DNA repair protein complexes that respond to DNA damage induced by environmental genotoxins and chemotherapy and how this pathway affects the regulation of cellular metabolism via ADP-ribosylation signaling and alterations in NAD+ metabolism.  Recent efforts have focused on the role of DNA repair pathways and the regulation of PARP1/PARP2 activation in response to replication stress, identification of novel targets to overcome PARP-inhibitor resistance and the development of novel biological tools and assays to evaluate genotoxic stress and PARP-activation that may be used for the discovery of novel compounds that may be used in the treatment of cancer and evaluating genotoxin response.

This is a fixed term position with a current end date of one year from hire, which may be extended based upon available funding.

Job Qualifications:
Education and Experience:
  • Required: Bachelor’s degree in Biology-related field (grade 7) and 1-2 years of experience (grade 8).
  • Preferred: Research experience in molecular biology or cancer biology
  • And/or equivalent combination of education and experience.
Job Competencies:
  • General background knowledge of cancer biology is a plus
  • Interest in scientific research
  • Ability to be organized and productive
  • Ability to keep accurate records
  • Ability to follow detailed instructions
  • Proficiency with computers and essential software programs (such as MS office)
  • Excellent verbal and written communications skills and be able to present complex data in clear presentations.
  • Ability to work independently as well as collaboratively with a diverse group of people, with vastly different skills and training.
  • Occasionally requires weekend hours for experimental monitoring
  • Possesses a willingness and ability to support a diverse and inclusive campus community

Recruiting Start Date:

Job Posting Title:
Research Assistant

Department of Pathology and Laboratory Medicine

Grade 7

Worker Type:

Worker Sub-Type:
Fixed Term (Fixed Term)

Time Type:
Full time

Scheduled Weekly Hours:

Position Classification:

Submission Guidelines:
Please note that in order to be considered an applicant for any staff position at Brown University you must submit an application form for each position for which you believe you are qualified. Applications are not kept on file for future positions. Please include a cover letter and resume with each position application.

Vaccination Requirements:
In order to maintain 90% or greater universal vaccination rates on campus, all newly hired employees at Brown University must receive the final dose of the COVID-19 vaccine before they begin work, unless they are approved for a medical or religious exemption. All employees must also receive a COVID-19 booster within thirty (30) days of becoming eligible. For more information, please visit the Healthy Brown site.

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EEO Statement:
Brown University is an E-Verify Employer.

As an EEO/AA employer, Brown University provides equal opportunity and prohibits discrimination, harassment and retaliation based upon a person’s race, color, religion, sex, age, national or ethnic origin, disability, veteran status, sexual orientation, gender identity, gender expression, or any other characteristic protected under applicable law, in the administration of its policies, programs, and activities.

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